Toxic Domain

Buff, Attack, AoE, Physical

Skill Gem · Tier 13

Level: 1–40

Cast Time: 1s

Create an area of Toxic Bloom on the ground around you. While in the Bloom, you have increased Skill costs, Regenerate Life, and your Projectile Attacks attach a Toxic Pustule, which can be Poisoned. Pustules will Detonate after a duration or when enough Poison has been applied, dealing more damage based on the stored Poison damage and applying Poison in an area around it.

At level 1

+3 metres to Toxic Bloom radius
Toxic Bloom duration is 8 seconds
Each enemy can have up to 1 Pustule attached
Life regeneration per second @4
Skill cost increase@25%
Projectile Hits attach a Pustule

At level 40

+3 metres to Toxic Bloom radius
Toxic Bloom duration is 8 seconds
Each enemy can have up to 1 Pustule attached
Life regeneration per second @76
Skill cost increase@25%
Projectile Hits attach a Pustule

Toxic Domain is a tier 13 Dexterity skill gem in Path of Exile 2 (Buff, Attack, AoE, Physical). Support gems that can support it: 202.

Published Sep 27, 2026 · patch 0.5.5 Forbidden Rites

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Tier: 13
Level: 1–40
Cast Time: 1s
Tags: Buff, Attack, AoE, Physical, Chaos, Duration, Plant
Support Gems: 202

Per level

Level	Cost	Toxic Domain Healing Per Minute
1	24	240
2	27	348
3	31	456
4	34	564
5	38	672
6	41	780
7	45	888
8	49	996
9	53	1104
10	57	1212
11	61	1320
12	66	1428
13	70	1536
14	75	1644
15	80	1752
16	85	1860
17	90	1968
18	95	2076
19	101	2184
20	106	2400
21	112	2508
22	118	2616
23	124	2724
24	130	2832
25	137	2940
26	144	3048
27	151	3156
28	158	3264
29	165	3372
30	173	3480
31	180	3588
32	188	3696
33	196	3804
34	205	3912
35	214	4020
36	222	4128
37	232	4236
38	241	4344
39	251	4452
40	261	4560

Support gems for Toxic Domain (202)

Toxic Domain

Per level

Support gems for Toxic Domain (202)

Attack (28)

Lineage (25)

Physical (23)

Fire (13)

Chaos (11)

Spell (11)

Cold (10)

Lightning (10)

AoE (9)

Duration (7)

Minion (4)

Warcry (2)

Payoff (1)

Other (48)